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Furthermore, CatG participates in complex inflammatory response regulation processes, including cytokine, chemokine, and growth factor processing and activation, as well as apoptosis induction through protease three pathways ( In pathological states such as bronchiectasis and COPD, NSP activity in sputum and bronchoalveolar lavage fluid increases markedly, with activity levels correlating positively with disease severity, acute exacerbation risk, and lung function decline rates ( 2.3 Role of DPP1 in NSP activation DPP1 plays an essential role in activating NSP precursor proteins during neutrophil maturation

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In studies with adult female rats injected with methylprednisolone (a glucocorticoid), simultaneous administration of ipamorelin 100 g/kg three times daily for 3 months significantly increased maximum tetanic tension of calf muscles compared to the glucocorticoid-only group